44^th World Dental Science and Oral Health Congress

Biography

Biography: Shaista Suhail

Abstract

 Oral cancer continues to be the most prevalent cancer resulting from the consumption of tobacco, alcohol and other carcinogenic products. In nature more than 95% of the carcinomas of the oral cavity represent squamous cell type. They constitute a major health problem in developing countries including India, representing an increase in mortality rate leading to the cause of death. The survival index continues to be small (50%), as compared to the progress in treatment. The study was done to investigate the Telomere length of isolated DNA by terminal restriction fragment (TRF), Southern blot analysis. In the study a total of 100 samples of tissues from Oral cancer, precancer cases and oral normal mucosa patients were collected to the analyzed telomere length. The mean telomeric length of precancer and cancer patient’s was significantly found to be lower as compared to normal with p < .001. The range and mean of peak TRF length was calculated by using students  and paired t- test. The range of oral cancer samples was calculated to be 3.6 - 11.4 and mean ± SD was 6.4 ± 2.0 while of precancer samples range was 3.1- 11.0 and mean ± SD was calculated to be 6.8 ± 2.2. In normal samples range was 2.8–10.9 and mean ± SD was calculated to be 8.9 ± 2.6. On comparing the telomeric length in specimen at oral precancerous and cancerous stages it was found that telomeric length was found to be shorter in oral cancer than precancer and normal patients. The mean peak TRF length was significantly lower in OSCC and precancer specimens compared with normal (control) specimens with p< .001.